Postural Orthostatic Tachycardia Syndrome, commonly known as POTS, is a condition that is closely associated with Ehlers-Danlos Syndrome (EDS), Hypermobile Ehlers-Danlos Syndrome (hEDS), and Hypermobility Spectrum Disorders (HSD). A frequent comorbidity, Mast Cell Activation Syndrome (MCAS), can significantly disrupt individuals' quality of life, often overshadowing other aspects of EDS due to its multisystem nature. The complexity and numerous symptoms of these conditions can pose diagnostic challenges for many providers, as they often mimic other dysautonomia symptoms. Fortunately, various exercise programs designed for both children and adults are available online, created by medical professionals, and can be discussed with your primary care provider, electrophysiologist, or cardiologist. Additionally, Small Fiber Neuropathy (SFN) has been linked to EDS. Unfortunately, the medications typically prescribed for these conditions may lead to exacerbated symptoms or introduce new side effects. One of the latest approaches in functional medicine is the use of Low Dose Naltrexone treatment, which offers a new avenue for managing EDS patients' care. Implementing lifestyle changes is crucial for this patient population; nutritional adjustments such as vegan, gluten-free, and low histamine diets are among the recommended strategies. Moreover, incorporating holistic therapies like anti-inflammatory, low histamine, and antihistamine herbs, as well as mast cell stabilizers, can enhance the effectiveness of treatment by alleviating excess fluid that causes pain and swelling. Engaging with a patient portal can also facilitate better communication with healthcare providers to explore these options.